Azelaic acid is a kind of skin disease prevention and treatment drug, mainly used to treat acne, chloasma and skin melanin deposition. It is also an important organic synthesis intermediates, used in plastics, rubber and other industries to synthesize plasticizer, in aviation oil Chemicalbook used in the synthesis of low temperature high speed lubricating oil, electrolytic capacitor manufacturing and other aspects have important applications. The preparation of azelaic acid from unsaturated fatty acids such as oleic acid and corresponding triglycerides such as castor oil and cottonseed oil is the main production method at present.

Azelaic acid can inhibit or kill anaerobic bacteria and aerobic bacteria in skin parts. In vivo test showed that local application of azelaic acid cream, continuous 2 ~ 3 months, can significantly reduce the number of skin bacteria and propionibacillus bacteria in hair follicles, indicating that this product has a direct antibacterial effect. In addition, local application of azelaic acid can reduce the composition of free fatty acids and lipids on the skin surface. It shows anti-keratinizing effect on the skin of normal people and acne patients, mainly due to the reduction of Chemicalbook filamentous keratin synthesis, thereby reducing hair follicle hyperkeratinization. Azelaic acid selectively acts on abnormal melanocytes and inhibits their overactivity. Therefore, local application of azelaic acid for a long time can reduce the generation of skin melanin in senile plaques. However, this product has no effect on normal skin pigment. Azelaic acid can also inhibit cell proliferation and cytotoxicity by disrupting mitochondrial respiratory pathway and DNA synthesis.