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Ceftobiprole CAS 209467-52-7 In stock CAS NO.209467-52-7
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Keywords
- Ceftobiprole
- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(2Z)-2-(5-aMino-1,2,4-thiadiazol-3-yl)-2-(hydroxyiMino)acetyl]aMino]-8-oxo-3-[(E)-[(3'R)-2-oxo[1,3'-bipyrrolidin]-3-ylidene]Methyl]-,(6R,7R)-
- CAS 209467-52-7
Quick Details
- ProName: Ceftobiprole CAS 209467-52-7 I...
- CasNo: 209467-52-7
- Molecular Formula: CAS 209467-52-7
- Appearance: As per COA
- Application: It is an important raw material and in...
- DeliveryTime: within 5days upon order
- PackAge: export standard
- Port: SHANGHAI or any port in China
- ProductionCapacity: 5 Metric Ton/Day
- Purity: high quality
- Storage: high quality and we have in stock
- Transportation: By AIR or by SEA
- LimitNum: 1 Metric Ton
- Moisture Content: < 0.5%
- Impurity: < 0.5%
- Grade: Industrial Grade
Superiority
Ceftobiprole CAS 209467-52-7 In stock
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(2Z)-2-(5-aMino-1,2,4-thiadiazol-3-yl)-2-(hydroxyiMino)acetyl]aMino]-8-oxo-3-[(E)-[(3'R)-2-oxo[1,3'-bipyrrolidin]-3-ylidene]Methyl]-,(6R,7R)-
| Product Name: | Ceftobiprole |
| Synonyms: | Ceftobiprole;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(2Z)-2-(5-aMino-1,2,4-thiadiazol-3-yl)-2-(hydroxyiMino)acetyl]aMino]-8-oxo-3-[(E)-[(3'R)-2-oxo[1,3'-bipyrrolidin]-3-ylidene]Methyl]-,(6R,7R)- |
| CAS: | 209467-52-7 |
| MF: | C20H22N8O6S2 |
| MW: | 534.576 |
| EINECS: | |
| Product Categories: | - |
| Mol File: | 209467-52-7.mol |
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| Ceftobiprole Chemical Properties |
| Safety Information |
| Ceftobiprole Usage And Synthesis |
| Uses | Broad spectrum antibiotic. |
| Antimicrobial activity |
The most important property distinguishing it from older cephalosporins is activity against methicillin-resistant staphylococci, a property conferred by a high affinity for penicillinbinding protein 2′ (2a). MICs for methicillin-resistant strains are nevertheless somewhat higher than those seen with fully susceptible strains. A similar situation exists with coagulasenegative staphylococci and with Str. pneumoniae, for which strains with reduced susceptibility to penicillin are less susceptible than fully resistant strains, while remaining within therapeutically achievable levels. Otherwise activity approximates to that of cephalosporins of group 4 . Activity against Ps. aeruginosa is modest and much reduced against ceftazidime-resistant strains. |
| Acquired resistance | It is hydrolyzed by extended spectrum β-lactamases of enterobacteria , which are therefore resistant. The prospects for the emergence of resistance during extensive clinical use are presently unclear, though increased resistance in Staph. aureus appears to be difficult to induce under laboratory conditions. |
| Pharmacokinetics |
Cmax 500 mg (667 mg prodrug): c. 35 mg/L end infusion intravenous (30-min infusion) Plasma half-life: c. 3 h Volume of distribution: 18.4 L Plasma protein binding: 16% The prodrug is rapidly hydrolyzed in plasma to release the active form together with diacetyl (2,3-butanediol) and CO2. Distribution approximates to the extracellular fluid volume in adults. There is no accumulation on repeat dosing in subjects with normal renal function. It is chiefly excreted in urine by glomerular filtration. A urinary concentration exceeding 1 g/L is achieved within the first 2 h of a 500 mg (active drug equivalent) dose and 80–90% of active drug can be recovered within 24 h. |
| Clinical Use | Ceftobiprole can be used as Broad spectrum antibiotic and in complicated infections of skin and skin structures. |
| Side effects | Limited studies have so far revealed no unexpected side effects. Nausea, vomiting and altered taste sensation appear to be the most common. |
| Ceftobiprole Preparation Products And Raw materials |
Chemwill Asia co.,Ltd is one of the leading manufacturer in CHINA.
Our main production base is located in Xuzhou industry park. We produce a wide range of organics including Basic chemicals , Fine chemicals, Active pharmaceutical ingredients(APIs), Veterinary, Indole derivatives, Aromatics, Fluorine, Boronic acids, organocatalysts, chiral building blocks, heterocyclic compounds. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.
Our R&D team masters core technology for process-design of target building block as well as Tailor-made fine chemicals. Our manufactory specialised in extreme temperature conditions (-100ºC to +300ºC), hydrogenations reaction under high pressure, suzuki coupling reaction, photochemical reaction, Mitsunobu reactions, enantioselective reactions and asymmetric synthesis.
Think Chemistry,Think CHemWill
Factory Plant Address:
High-Tech Industrial park,Chemical Economical Development Zone,Xuzhou, Jiangsu-Province, P.R.China
Shanghai office: (Export Department)
Address: 16FL., INDUSTRY & COMMERCIAL BUILDING, NO.45 YAN’AN ROAD(E), 200002, SHANGHAI, CHINA
Details
Think Chemistry,Think CHemWill
Factory Plant Address:
High-Tech Industrial park,Chemical Economical Development Zone,Xuzhou, Jiangsu-Province, P.R.China
Shanghai office: (Export Department)
Address: 16FL., INDUSTRY & COMMERCIAL BUILDING, NO.45 YAN’AN ROAD(E), 200002, SHANGHAI, CHINA