Product Name: Thioacetamide
Synonyms:
Ethanethioamide
CAS RN.:
62-55-5
EINECS: 200-541-4
Molecular Weight: 75.1328
Molecular Formula: C2H5NS
Density: 1.07g/cm3
Melting Point(℃): 112-114℃
Boiling Point(℃): 111.7°C at 760 mmHg
Flash Point(℃): 21.4°C
refractive_index: 1.543
Water Solubility: 16.3 g/100 mL (25℃)
Properties
Density 1.37
Melting point 112-114 ºC
Water solubility 16.3 g/100 mL (25 ºC)
Thioacetamide is an organosulfur compound with the formula C2H5NS. This white crystalline solid is soluble in water and serves as a source of sulfide ions in the synthesis of organic and inorganic compounds. It is a prototypical thioamide.
Basic Info
Chemical Name thioacetamide
Synonyms
thio-acetamid;
Thioactamide;
CH3CSNH2;
Ethanethioamide;
USAF cb-21;
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CAS No. 62-55-5
Molecular Formula C2H5NS
Molecular Weight 75.13280
PSA 58.11000
LogP 0.99270
Properties
Appearance & Physical State white solid
Density 1.37
Boiling Point 111.7ºC at 760 mmHg
Melting Point 112-114ºC
Flash Point 21.4ºC
Refractive Index 1.543
Water Solubility 16.3 g/100 mL (25 ºC)
Stability Stability Incompatible with water, mineral acids.
Storage Condition Store at RT.
Safety Info
RTECS AC8925000
Safety Statements S45-S53-S61
HS Code 2942000000
WGK Germany 3
RIDADR 2811
Risk Statements R22; R36/38; R45; R52/53
Hazard Codes T
Thioacetamide Basic information
Organic reagents Chemical properties Uses Production method
Product Name: Thioacetamide
Synonyms: THIOACETAMIDE XTL;Acetamide, thio-;Acetimidic acid, thio-;Acetothioamide;CH3CSNH2;Rcra waste number U218;rcrawastenumberu218;Thiacetamide
CAS: 62-55-5
MF: C2H5NS
MW: 75.13
EINECS: 200-541-4
Product Categories: -;Sulphur Derivatives;Building Blocks;Chemical Synthesis;Organic Building Blocks;Sulfur Compounds;Thiocarbonyl Compounds;API
Mol File: 62-55-5.mol
Thioacetamide Structure
Thioacetamide Chemical Properties
Melting point 108-112 °C(lit.)
density 1.37
refractive index 1.5300 (estimate)
storage temp. Store at RT.
solubility passes test2%
form Liquid
color Off-white to slightly beige
PH 5.2 (100g/l, H2O, 20℃)
Water Solubility 16.3 g/100 mL (25 ºC)
Merck 14,9319
BRN 506006
Stability: Stability Incompatible with water, mineral acids.
InChIKey YUKQRDCYNOVPGJ-UHFFFAOYSA-N
CAS DataBase Reference 62-55-5(CAS DataBase Reference)
NIST Chemistry Reference Ethanethioamide(62-55-5)
EPA Substance Registry System Ethanethioamide(62-55-5)
Safety Information
Hazard Codes T
Risk Statements 45-22-36/38-52/53
Safety Statements 53-45-61-99
RIDADR 2811
WGK Germany 3
RTECS AC8925000
F 10
TSCA Yes
HS Code 29309070
Hazardous Substances Data 62-55-5(Hazardous Substances Data)
Toxicity MLD orally in rats: 200 mg/kg (Ambrose)
MSDS Information
Provider Language
Ethanethioamide English
SigmaAldrich English
ACROS English
ALFA English
Thioacetamide Usage And Synthesis
Organic reagents Thioacetamide is organic reagent, it is colorless or white crystalline flake. It is dissolved in water, ethanol, very slightly soluble in benzene, ether, the aqueous solution at room temperature or 50~60℃ is fairly stable, when placed 2 to 3 weeks, it is not change, but when hydrogen ions is in the presence, it quickly decomposes into hydrogen sulfide , but hydrolysis increases with alkalinity or acidity of the solution and the temperature rises quickly. Hydrolysis equations solution of thioacetamide in acidic and basic is:
Acidic solution: CH3CSNH2 + 2H2O----(NH4 +) + CH3COO-+ H2S
Alkaline solution: CH3CSNH2 + 2OH-----NH3 + CH3COO-+ HS-
Since H2S or HS-can generate for hydrolysis in acidic or alkaline solution, so in analytical chemistry, it is often used in place of toxic and odor H2S, as the metal cation group reagents or precipitation reagents. The property of resulting precipitate is good, easy to separate. In addition, it can also be used for bismuth measurement reagent. Preparation method: It can be prepared by heating the acetamide with aluminum sulfide, hydrogen sulfide reacting with acetonitrile, or acetamide reacting with K3PS4.
Chemical properties It is colorless or white crystals. Mp is 113-114℃, the solubility in water is 16.3g/100ml at 25℃, ethanol 26.4g/100ml. It is slightly soluble in benzene, ether. Their solution is quite stable at room temperature or 50-60℃, but when hydrogen ions exists, it can generate thiosulfate hydrogen and decompose quickly. New product sometimes has mercaptan odor, slight moisture absorption.
The above information is edited by the chemicalbook of Wang Xiaodong.
Uses 1. It can be used for the production of catalysts, stabilizers, polymerization inhibitors, electroplating additives, photographic chemicals, pesticides, dyeing auxiliary and processing agents. It can be also used as polymer curing agents, crosslinking agents, rubber additives and pharmaceutical raw materials.
2. It can be also used as vulcanizing agent and crosslinking agent of polymer, rubber additives, pharmaceutical raw materials, etc.
3. It can be also used as analytical reagents.
Production method Thioacetamide can be obtained by the reaction of acetonitrile with hydrogen sulfide, or acetamide with phosphorus pentasulfide.
Chemical Properties Thioacetamide is combustible, crystalline compound. Slight mercaptan odor.
Chemical Properties White solid
Uses Sulfide generation
Uses Substitute for H2S in laboratory qualitative analyses.
Uses It is used as an intermediate in organicsynthesis.
Definition ChEBI: A thiocarboxamide consiting of acetamide having the oxygen replaced by sulfur.
General Description White crystals with a mercaptan odor.
Air & Water Reactions Slightly water soluble.
Reactivity Profile Thioacetamide reacts with aqueous acid to generate hydrogen sulfide. Forms addition compounds and sulfides with salts of heavy metals. Hydrolyzed by acids or bases .
Thioacetamide Preparation Products And Raw materials
Preparation Products 3-(2-METHYL-1,3-THIAZOL-4-YL)BENZOIC ACID-->2-(2,5-DIMETHYL-1,3-THIAZOL-4-YL)ACETIC ACID-->METHYL 2-(2,5-DIMETHYL-1,3-THIAZOL-4-YL)ACETATE-->2,4-Dimethylthiazole-5-carboxylic acid-->Aspoxicillin-->2-Methyl-1,3-thiazole-4-carboxylic acid-->ETHYL 2-METHYLTHIAZOLE-4-CARBOXYLATE
Raw materials Phosphorus pentasulfide-->Acetamide
China (Mainland)
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