Dimethyl sulfoxide CAS 67-68-5 In stock DMSO Methyl sulfoxide Sulfinylbis (methane) CAS NO.67-68-5

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Dimethyl sulfoxide
3-Benzofuranylboronic acid
CAS 67-68-5

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CasNo: 67-68-5
Molecular Formula: CAS 67-68-5
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Dimethyl sulfoxide CAS 67-68-5 In stock DMSO Methyl sulfoxide Sulfinylbis (methane)

67-68-5

CAS 67-68-5

Dimethylsulfoxide; Methyl sulfoxide; Sulfinylbis (methane); DMSO

Product Name: Methyl sulfoxide

Synonyms:

Dimethyl sulfoxide; DMSO; Methyl sulphoxide; methyl sulfoxide B&J brand 1 L; methyl sulfoxide absolute over molecular sieve (H2O <0.01%); Diemthyl Sulfoxide; Dimethyl Sulfoxide BP; Dimethyl sulphoxide; DMSO/NMP (Dimethylsulfoxide/1-Methyl-2-pyrrolidone); DMSO; Dimethylsulfoxide Sulfinylbis

CAS RN.:

67-68-5

EINECS: 200-664-3

Molecular Weight: 78.12

Molecular Formula: C2H6OS

Density: 1.1

Melting Point(℃): 18.4-19.0℃

Boiling Point(℃): 189℃

Flash Point(℃): 95℃

refractive_index: 1.477-1.48

Dimethyl sulfoxide (DMSO) is an organosulfur compound with the formula (CH3)2SO. This colorless liquid is an important polar aprotic solvent that dissolves both polar and nonpolar compounds and is miscible in a wide range of organic solvents as well as water. It has a relatively high melting point. DMSO has the unusual property that many individuals perceive a garlic-like taste in the mouth after contact with the skin.

In terms of chemical structure, the molecule has idealized Cs symmetry. It has a trigonal pyramidal molecular geometry consistent with other three-coordinate S(IV) compounds, with a nonbonded electron pair on the approximately tetrahedral sulfur atom.

Basic Info

Chemical Name Dimethyl sulfoxide

Synonyms

Methane, sulfinylbis-;

(Methylsulfinyl)methane;

CAS No. 67-68-5

Molecular Formula C2H6OS

Molecular Weight 78.13340

PSA 36.28000

LogP 0.86040

Properties

Appearance & Physical State colorless liquid

Density 1.1

Boiling Point 189ºC

Melting Point 18.4-19.0ºC

Freezing Point 18.4℃

Flash Point 95ºC

Refractive Index 1.477-1.48

Stability Stable. Incompatible with a very wide range of materials, including acid chlorides, strong acids, strong oxidizing agents, strong reducing agents, phosphorus halides, moisture, copper wool + trichloroacetic acid. Reacts violently with a number of materials

Storage Condition Store at RT.

Vapor Density 2.7 (vs air)

Vapor Pressure 0.42 mm Hg ( 20 °C)

Safety Info

RTECS PV6210000

Safety Statements S26-S37/39

HS Code 29309070

WGK Germany 1

Risk Statements R36/37/38

Hazard Codes Xi

Dimethyl sulfoxide Basic information

Overview Method of purification and water removal Identification and detection methods Reference quality standards Toxicity Limited use Recovery process Chemical Properties Uses Production method

Product Name: Dimethyl sulfoxide

Synonyms: Dromisol;Durasorb;Gamasol 90;gamasol90;Herpid;Hyadur;Infiltrina;Kemsol

CAS: 67-68-5

MF: C2H6OS

MW: 78.13

EINECS: 200-664-3

Product Categories: Pharmaceutical Intermediates;INORGANIC & ORGANIC CHEMICALS;Organics;Analytical Chemistry;Solvents for HPLC & Spectrophotometry;Serum-free Media;Stem Cell Biology;Cell Biology;Cell Signaling and Neuroscience;Core Bioreagents;Cryopreservation;General Reagents;Research Essentials;Apoptosis and Cell Cycle;Life Science Reagents for Nucleic Acid Purification;Life Science Reagents for Protein Expression and Purification;Other Apoptosis Related Reagents;Biostabilization Agents;PCR Optimization;Stabilization of Biomolecules;Biochemicals and Reagents;Life Science Reagents for PCR;Molecular Biology;PCR Reaction Components;PCR/Amplification;Plant Biotechnology;Plant Growth Regulators;Plant Tissue Culture;Primary Human Cell Culture;Specialty Media Systems;-;Hepatocytes;Biotech;Biotech Solvents;Life Science Reagents for Northern and Southern Blotting;Products;Returnable Containers;Sure/Seal Bottles;DMSO - Dimethyl sulfoxide;Molecular Biology Reagents;β;Analytical and Industrial Enzymes;and Substrates;Universal Solvent;Solvents for Spectrophotometry;Sulfur Compounds (for Synthesis);Synthetic Organic Chemistry;Dimethyl Sulfoxide (DMSO);Anhydrous Solvents;Solvent by Application;Solvent by Type;Solvents;Plastic Bottles;Analytical Reagents;Analytical Reagents for General Use;Analytical/Chromatography;C-D;Puriss p.a. ACS;Solvent Bottles;Solvent Packaging Options;BRDU Cell Proliferation Assay Reagents;Cell Culture;Cell Freezing Media and Reagents;Chemical ER Chaperones;Endoplasmic Reticulum Stress;General Stem Cell Biology;Hybridoma Platform;Hybridoma Reagents;Life Science Reagents for Cell Culture;Reagents and Supplements;Biochemicals;Enzymes;-Glucuronidase;-Glucuronidase Drug Analysis Bundle;Inhibitors;Life Science Reagents for RNAi;Anhydrous;ACS and Reagent Grade Solvents;ACS Grade;ACS Grade Solvents;Amber Glass Bottles;Composite Drums;Drums Product Line;Semi-Bulk Solvents;VerSA-Flow Products;CHROMASOLV Plus;Chromatography Reagents &;HPLC &;HPLC Plus Grade Solvents (CHROMASOLV);HPLC/UHPLC Solvents (CHROMASOLV);NOWPak Products;UHPLC Solvents (CHROMASOLV)

Mol File: 67-68-5.mol

Dimethyl sulfoxide Structure

Dimethyl sulfoxide Chemical Properties

Melting point 18.4 °C

Boiling point 189 °C(lit.)

density 1.100 g/mL at 20 °C

vapor density 2.7 (vs air)

vapor pressure 0.42 mm Hg ( 20 °C)

refractive index n20/D 1.479(lit.)

FEMA 3875 | METHYLSULFINYLMETHANE

Fp 192 °F

storage temp. Store at RT.

solubility H2O: miscible (completely)

form liquid (temperature dependent)

pka 35(at 25℃)

color clear colorless

Relative polarity 0.444

Odor Mild garlic odor

explosive limit 1.8-63.0%(V)

Water Solubility Soluble in water, methanol, acetone, ether, benzene, chloroform.

FreezingPoint 18.4℃

Sensitive Hygroscopic

λmax λ: 285 nm Amax: ≤0.20

λ: 295 nm Amax: ≤0.20

Merck 14,3259

JECFA Number 507

BRN 506008

Stability: Stable. Incompatible with a very wide range of materials, including acid chlorides, strong acids, strong oxidizing agents, strong reducing agents, phosphorus halides, moisture, copper wool + trichloroacetic acid. Reacts violently with a number of materials - consult a full data sheet before use. Hygroscopic.

InChIKey IAZDPXIOMUYVGZ-UHFFFAOYSA-N

CAS DataBase Reference 67-68-5(CAS DataBase Reference)

NIST Chemistry Reference Dimethyl sulfoxide(67-68-5)

EPA Substance Registry System Methane, sulfinylbis-(67-68-5)

Safety Information

Hazard Codes Xi

Risk Statements 36/37/38

Safety Statements 24/25-37/39-26-36-23

RIDADR NA 1993 / PGIII

WGK Germany 1

RTECS PV6210000

F 3

Autoignition Temperature 215 °C

TSCA Yes

HS Code 29309070

Dimethyl sulfoxide (abbreviated DMSO) is a sulfur-containing organic compound; molecule formula: (CH3) 2SO; It exhibits as colorless, odorless, hygroscopic and flammable transparent liquid at room temperature. It has both high polarity as well as high-boiling point. It also has aprotic and water-miscible characteristics. It has low toxicity, good thermal stability, and is not miscible with paraffin. It is soluble in water, ethanol, propanol, ether, benzene and chloroform and many other kinds of organic substance and is called as the "universal solvent." It is a common organic solvent which has the strongest dissolving ability. It can dissolve most the organic compounds including carbohydrates, polymers, peptides, as well as many inorganic salts and gases. It can dissolve certain amount solute whose weight is equals to 50-60% of itself (other common solvents usually only dissolve 10-20%), so it is very important in the sample management as well as high-speed screening of drugs. Under certain conditions, contact between dimethyl sulfoxide and chloride can even lead to explosive reaction.

dimethyl sulfoxide is widely used as solvents and reagents, particularly as the processing reagent and spinning solvent at the reaction of acrylonitrile polymerization used for polyurethane synthesis and the spinning solvent. It can also be used as the synthetic solvent for polyamide, polyimide and polysulfone resin as well as the extraction solvents for aromatic hydrocarbon and butadiene extraction solvents and solvents for synthesizing chlorofluoroaniline. In addition, dimethyl sulfoxide can also be directly used as the raw material or carrier of some drug in the pharmaceutical industry. dimethyl sulfoxide itself has various effects such as anti-inflammatory, analgesic, diuretic, and sedative, and thus also being known as "panacea" which is usually as the active ingredient of analgesic medication being added to the drug. It also has special properties of easy penetration through the skin, resulting in personnel feeling of oyster-like flavor. The dimethyl sulfoxide solution of sodium cyanide can cause cyanide poisoning through skin contact while dimethyl sulfoxide itself has a relative low toxicity. dimethyl sulfoxide is widely applied as the extraction agent in a lot of chemical and pharmaceutical companies. However, because of its higher boiling point, it causes very high operating temperatures and further causes the coking of materials, thus affecting the recycling of dimethyl sulfoxide and further cleaning of the equipments as well as resulting in increased energy consumption. Therefore, the recycling of dimethyl sulfoxide has become a bottleneck as its further wide application as extraction agent.

The above information is edited by the Chemicalbook of Dai Xiongfeng.

Method of purification and water removal dimethyl sulfoxide can be mixed with water and can be placed for long term storage and drying through molecular sieve. Further apply it to vacuum distillation and collect the fraction of 76 °C/1600Pa (12mmHg). Upon distillation, keep the temperatures at below 90 °C; otherwise it will result in disproportionation reaction which generates dimethyl sulfone and dimethyl sulfide. It may also be dried through calcium oxide, calcium hydroxide, barium oxide and barium sulfates and then distilled under reduced pressure. It may also be purified through partially crystallization. It can lead to explosion when mixing the dimethyl sulfoxide with certain substance such as sodium hydride, periodic acid or magnesium perchlorate, and thus should be paid attention.

It is colorless liquid, and is hygroscopic. It is almost odorless with a bitter taste. It can be dissolved in water, ethanol, acetone, ether, benzene and chloroform.

Uses 1. It can be used for the extraction of arene, also as the reaction medium used for resins and dyes, and applied to acrylic polymerization and spinning solvent.

2. It can be used as an organic solvent, reaction medium and the intermediates of organic synthesis. It is highly versatile. This product has a highly selective extraction capacity, and can be used as the polymerization and condensation solvent of acrylic resin and polysulfone resin, as the polymerization and spinning solvent of polyacrylonitrile and cellulose acetate, as the extraction solvent for separating alkanes and arenes, and as the reaction medium for the arenes, butadiene extraction, acrylic fiber, plastic solvents, organic and synthetic dyes, and pharmaceuticals industries. In the field of medicine, dimethyl sulfoxide has anti-inflammatory and analgesic effect with a strong capability of penetration through the skin, and thus being able to dissolve certain drugs and boost their penetration into the human body to achieve the therapeutic purposes. Taking this carrier property of dimethyl sulfoxide can make it be used as pesticide additives. Add a small amount of dimethyl sulfoxide in some pesticides can facilitate the penetration of pesticides into the plant in order to improve the efficacy. dimethyl sulfoxide can also be used as the dye solvent, dye removing agent, and dye carrier for the synthetic fibers. It can also be used as the absorbent of recycling acetylene and sulfur dioxide and also the modifiers of synthetic fiber, antifreeze agent and the capacitor dielectric, brake oil, and extractant of the rare metals.

3. It can be used as analytic solvents and fixing agent of gas chromatography as well as the solvent for analyzing UV spectra.

Production method dimethyl sulfoxide is generally made by using dimethyl sulfide oxidation method. They have different production processes due to the different oxidants and oxidation types. 1. Methanol carbon disulfide method; take carbon disulfide and methanol as raw materials and use γ-Al2O3 as the catalyst; first synthesize the dimethyl sulfide, then have oxidation reaction with nitrogen dioxide (or nitrate) to obtain dimethyl sulfoxide. 2. The hydrogen peroxide method: take acetone as the buffer medium to have dimethyl sulfide be reacted with hydrogen peroxide. This method of dimethyl sulfoxide synthesis has a relative high cost and thus is suitable for large-scale production. 3. The method of nitrogen dioxide: have methanol and hydrogen sulfide dimethyl sulfide reacted in the catalysis of γ-alumina to obtain dimethyl sulfide; have sulfate reacted with sodium nitrite to generate nitrogen dioxide; dimethyl sulfide has gas-liquid phase reaction with nitrogen dioxide at 60-80 °C to produce crude dimethyl sulfoxide. Sometimes people also use oxygen for direct oxidation which also generates the crude dimethyl sulfoxide. Then after vacuum distillation, refine to get the finished product of dimethyl sulfoxide. This method is a relative advanced production method. 4. Dimethyl sulfate method: apply dimethyl sulfate to react with sodium sulfide to obtain dimethyl sulfide; sulfate has reaction with sodium nitrite to generate nitrogen dioxide; dimethyl sulfide is oxidized with nitrogen dioxide to generate the crude dimethyl sulfoxide, and then undergo neutralization and distillation to obtain refined dimethyl sulfoxide product. In addition, the anodic oxidation method can also produce dimethyl sulfoxide via dimethyl sulfide.

Chemical Properties Dimethyl sulfoxide occurs as a colorless, viscous liquid, or as colorless crystals that are miscible with water, alcohol, and ether. The material hasa slightly bitter taste with a sweet aftertaste, and is odorless, or has a slight odor characteristic of dimethyl sulfoxide.Dimethyl sulfoxide is extremely hygroscopic, absorbing up to 70% of its own weight in water with evolution of heat.

Occurrence Reported found in apple, raspberry, cabbage, cucumber, onion, tomato, peppermint and spearmint oils, milk, pork liver, beer, rum, cocoa, coffee, black tea, oatmeal, soybean, beetroot, parsnip root, watercress, sweet corn, malt, cooked shrimp and oysters

Uses DMSO is a polar aprotic solvent used in chemical reactions, in polymerase chain reactions (PCR) and as a cryoprotectant vitrification agent for the preservation of cells, tissues and organs. DMSO is used in cell freezing media to protect cells from ice crystal induced mechanical injury. It is used for frozen storage of primary, sub-cultured, and recombinant heteroploid and hybridoma cell lines; embryonic stem cells (ESC), and hematopoietic stem cells. DMSO is frequently used in the combinations with BSA or fetal bovine serum (FBS).

Uses Human and animal cell lines grown in culture are generally stored frozen. Freezing protects the cell line from changes due to genetic drift and minimizes risk of contamination. Liquid nitrogen used in conjunction with a cryoprotective agent such as DMSO is a widely used method for preserving cells. Without the presence of a cryoprotective agent, freezing is lethal to most mammalian cells. Damage is caused by mechanical injury by ice crystals, concentration of electrolytes, pH changes, and denaturation of proteins. These lethal effects are minimized by adding a cryoprotective agent which lowers

Uses Dimethyl sulfoxide (1-10%) has been shown to accelerate strand renaturation and is believed to give the nucleic acid thermal stability against depurination. As a PCR cosolvent, DMSO may help improve yields, especially in long PCR.

Uses A polar aprotic solvent used in polymerase chain reactions (PCR) and as a cryoprotectant vitrification agent for the preservation of cells, tissues and organs.

Uses Suitable for HPLC, spectrophotometry, environmental testing

Uses Solvent for many organic Compounds including fats, carbohydrates, dyes, resins, and polymers. In organic reactions. As antifreeze or hydraulic fluid when mixed with water. To cryopreserve and store cultured cells.

Dimethyl sulfoxide Preparation Products And Raw materials

Preparation Products [6-(1H-PYRAZOL-1-YL)PYRIDIN-3-YL]METHYLAMINE-->6-(1H-PYRAZOL-1-YL)NICOTINONITRILE-->4-(IMIDAZOL-1-YL)PHENOL-->5-Hydroxyanthranilic acid-->4-(1-METHYLPIPERIDIN-4-YLOXY)-3,5-DICHLOROBENZENAMINE-->4-(2-(DIMETHYLAMINO)ETHOXY)-3,5-DICHLOROBENZENAMINE-->4-(3-(DIMETHYLAMINO)PROPOXY)-3,5-DICHLOROBENZENAMINE-->5-Fluoro-2-oxindole-->3,5-DIMETHOXYPHENYLACETONITRILE-->5-Bromo-3-nitro-2-pyridinol-->4'-Phenoxyacetophenone-->3-PHENOXYANILINE-->(6-(1H-Pyrazol-1-yl)pyridin-3-yl)methanol-->Piperonyloyl chloride-->1-METHYL-4-(3-NITROPHENYL)PIPERAZINE-->4-Phenoxyphenol-->Ethyl 2,3-dicyanopropionate-->DIMEPIPERATE-->2-MORPHOLINOBENZOIC ACID-->1-(3-CYANOBENZYL)PIPERAZINE-->ETHYL 3-AMINOBENZOFURAN-2-CARBOXYLATE-->3-(1H-PYRAZOL-1-YL)ANILINE-->N-METHYL-6-(1H-PYRAZOL-1-YL)NICOTINAMIDE-->4-Piperazinobenzonitrile-->(4-FLUOROPHENOXY)ACETYL CHLORIDE-->5-METHOXY-2-METHYLPYRIDINE-->Rimantadine-->6-(1H-PYRAZOL-1-YL)NICOTINIC ACID-->4-MORPHOLINOBENZYLAMINE-->3-CHLOROPHENOXYACETYL CHLORIDE-->3-(4-Methylpiperazin-1-yl)aniline-->Methyl 6-(1H-pyrazol-1-yl)pyridine-3-carboxylate-->Levamisole-->Thiane-->2,4-Difluoro-3,5-dichloronitrobenzene-->A-(BROMOMETHYL)-A-BUTYL4-CHLOROBENZENEACETONITRILE-->Benzofluorfen-->1,8-Octanedinitrile-->Clomipramine hydrochloride-->Methyl sulfone

Raw materials Methanol-->Carbon disulphide-->Dimethyl sulfide-->NITROGEN DIOXIDE

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